| 摘要 |
PROBLEM TO BE SOLVED: To provide an apo crystal of reduced human galectin-1 having a structure in which a sugar chain recognition domain of the apo crystal of reduced human galectin-1 cannot bind to a sugar chain. ! SOLUTION: Disclosed is an apo crystal of the reduced human galectin-1 which forms homodimer, and in a monomer crystal structure of at least one of the above homodimer, in a base amino acid sequence consisting of a specific sequence, a loop consisted of an amino acid residue from the asparagine of the 50th to the alanine of the 55th is not bended in the direction of a β-sheet consisted of an amino acid residue from the asparagine of the 40th to the phenylalanine of the 49th and an amino acid residue from the asparagine of the 56th to the lysine of the 63rd. ! COPYRIGHT: (C)2014,JPO&INPIT |
