发明名称 |
COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY AND FIBROTIC DISORDERS |
摘要 |
Disclosed are compounds and methods for treating inflammatory and fibrotic disorders, including methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of the p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the p38 MAPK by the compound. Also disclosed are derivatives and analogs of pirfenidone, useful for modulating a stress activated protein kinase (SAPK) system. |
申请公布号 |
US2014235637(A1) |
申请公布日期 |
2014.08.21 |
申请号 |
US201414263822 |
申请日期 |
2014.04.28 |
申请人 |
InterMune, Inc. |
发明人 |
Kossen Karl;Seiwert Scott D.;Serebryany Vladimir;Ruhrmund Donald;Beigelman Leonid D.;Raveglia Luca Francesco Mario;Vallese Stefania;Bianchi Ivana;Hu Tao |
分类号 |
C07D213/64;C07D417/04;C07D409/04;C07D405/04;C07D213/85 |
主分类号 |
C07D213/64 |
代理机构 |
|
代理人 |
|
主权项 |
1. (canceled) |
地址 |
Brisbane CA US |