发明名称 |
TYROSINE DERIVATIVE AND MANUFACTURING METHOD FOR TYROSINE DERIVATIVE |
摘要 |
The objective of the present invention is to provide a tyrosine derivative which is useful as a melatonin receptor MT1 antagonist, and a method for efficiently manufacturing a specific m-tyrosine derivative in which an iodine atom is introduced to the paraposition of a phenolic hydroxl group on the benzene ring of m-tyrosine with excellent regioselectivity and high yield. This tyrosine derivative is characterized by being represented by formula (I). [In the formula, R1 represents an amino group protecting group or the like, R2 represents a carboxy group protecting group or the like, R3 represents a hydrogen atom or the like, R4 represents a halogen atom or the like, A represents -(CH2)l-[Z(CH2)m]n-, and X represents a leaving group.] |
申请公布号 |
WO2014103998(A3) |
申请公布日期 |
2014.08.21 |
申请号 |
WO2013JP84452 |
申请日期 |
2013.12.24 |
申请人 |
NARD INSTITUTE, LTD. |
发明人 |
NAKAO, HIDEKAZU;HOSHINO, JUNICHI;OGATA, TOKUTARO;MIYASHITA, NAOKI;YAMAMOTO, YOSHIKAZU |
分类号 |
C07C309/73;C07B57/00;C07C269/06;C07C271/22;C07C303/30;C07F7/18 |
主分类号 |
C07C309/73 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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