| 发明名称 |
FIBROBLASTS CELLULAR MODEL FOR ASSESSING EFFICACY OF CANCER TREATMENTS BY SHH/PTCH PATHWAY ANTAGONISTS |
| 摘要 |
A cellular model is described that targets dysregulation or inappropriate activation of the Sonic Hedgehog/Patched (SHH/PTCH) pathway. Also described, is a screening method using this cellular model to screen for pharmacological compounds that can treat or prevent skin cancer, in particular, Basal Cell Carcinoma, (BCC) lesions. |
| 申请公布号 |
US2014235856(A1) |
申请公布日期 |
2014.08.21 |
| 申请号 |
US201214346886 |
申请日期 |
2012.09.24 |
| 申请人 |
CNRS ;GALDERMA RESEARCH & DEVELOPMENT |
发明人 |
Burty Elodie;Magnaldo Thierry;Gache Yannick |
| 分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An immortalized cell line of human fibroblasts from a healthy individual having NBCCS or Gorlin syndrome with a natural endogenous GLI 1 gene that has a stable expression and inducibility over time. |
| 地址 |
Paris FR |
