| 发明名称 |
NGF APTAMER AND APPLICATION THEREOF |
| 摘要 |
The present invention provides an aptamer binding to NGF and capable of forming a potential secondary structure represented by the formula (I):;;wherein N is one nucleotide selected from the group consisting of A, G, C, U and T,
N11-N13, N21-N23, N32-N38 and N42-N48 are the same or different and each is a bond or 1 or 2 nucleotides selected from the group consisting of A, G, C, U and T,N14, N24, N31, N41, N39 and N49 are the same or different and each is one nucleotide selected from the group consisting of A, G, C, U and T,N14 and N24, N31 and N41, and N39 and N49 each form a Watson-Crick base pair,N11-N12-N13-N14 and N21-N22-N23-N24 are nucleotide sequences capable of forming a stem structure in combination, andN31-N32-N33-N34-N35-N36-N37-N38-N39 and N41-N42-N43-N44-N45-N46-N47-N48-N49 are nucleotide sequences capable of forming a stem structure in combination. |
| 申请公布号 |
US2014235701(A1) |
申请公布日期 |
2014.08.21 |
| 申请号 |
US201214347738 |
申请日期 |
2012.09.28 |
| 申请人 |
RIBOMIC INC. |
发明人 |
Jin Ling;Hiramatsu Hisanao |
| 分类号 |
C12N15/115 |
主分类号 |
C12N15/115 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An aptamer binding to NGF and capable of forming a potential secondary structure represented by the formula (I): wherein N is one nucleotide selected from the group consisting of A, G, C, U and T, N11-N13, N21-N23, N32-N38 and N42-N48 are the same or different and each is a bond or 1 or 2 nucleotides selected from the group consisting of A, G, C, U and T, N14, N24, N31, N41, N39 and N49 are the same or different and each is one nucleotide selected from the group consisting of A, G, C, U and T, N14 and N24, N31 and N41, and N39 and N49 each form a Watson-Crick base pair, N11-N12-N13-N14 and N21-N22-N23-N24 are nucleotide sequences capable of forming a stem structure in combination, and N31-N32-N33-N34-N35-N36-N37-N38-N39 and N41-N42-N43-N44-N45-N46-N47-N48-N49 are nucleotide sequences capable of forming a stem structure in combination. |
| 地址 |
Tokyo JP |
