Pyridine Derivatives

摘要

The present application provides novel pyridine compounds and pharmaceutically acceptable salts or prodrugs thereof. Also provided are methods for preparing these compounds. These compounds are useful in inhibiting CYP17 activity by administering a therapeutically effective amount of one or more of the compounds to a patient. By doing so, these compounds are effective in treating conditions associated with CPY17 activity. A variety of conditions can be treated using these compounds and include diseases which are characterized by abnormal cellular proliferation. In one embodiment, the disease is cancer, such as prostate cancer.

主权项

1. A compound of formula (I) of the structure:wherein:
A is optionally substituted phenyl or optionally substituted heteroaryl; B is optionally substituted heteroaryl; Q is O or NH; R′ is:
(a) H, or C1 to C4 alkyl; or(b) two or three methylene fragments that are joined to a carbon atom at the 3-position of the pyridine ring;or a pharmaceutically acceptable salt or prodrug thereof.