PHARMACEUTICAL COMPOUNDS FOR USE IN THE THERAPY OF CLOSTRIDIUM DIFFICILE INFECTION

摘要

The invention relates to a compound described by a general formula (1), wherein each X independently can be OPO32−, OPSO22− or OSO3−; R1 comprises a solubility function such as a polyethylene glycol moiety and each X independently can be OPO32−, OPSO22−, − or OSO3−; and Z is an alkyl chain comprising 1 to 3 carbon and/or hetero atoms. The invention further relates to polysulfate derivatives or mixed polyphosphate/sulphate derivatives of six-membered cyclic polyols for use in the therapy of infection by Clostridium difficile.

主权项

1. A compound described by a general formula (1) wherein R1 comprises a solubility function R2 selected from the group including
a polyethylene glycol;a monosaccharide, oligosaccharide or polysaccharide,a polyglycerol,a polymer or copolymer comprising a plurality of any of the monomers hydroxypropyl methacrylamide (HPMA), hydroxyethyl methacrylate (HEMA), vinyl alcohol (VA), vinyl pyrrolidone (VP), N-isopropyl acrylamide (NIPAM) and/or PEG methacrylate (PEGMA) with n and m independently having a value from 3 to 200;a poly(styrene-co-maleic acid/anhydride)a C3-C10 alkyl comprising at least three substituent functions independently selected from the group including an amine-, hydroxy-, thiol-, carboxylic acid, carboxylic amide, sulfonic acid or sulfonamide function,each X independently is selected from OPO32−, OPSO22−, − or OSO3−; andZ is an alkyl chain comprising 1 to 3 carbon and/or hetero atoms.