| 主权项 |
1. A method of treating or preventing infections with H5N1 virus of a different clade comprising administering to a subject an H5 protein of clade 1 H5N1 virus, wherein said H5 protein comprises a polypeptide sequence having at least 98% sequence identity with the polypeptide sequence of SEQ ID NO:1, wherein said H5N1 virus of a different clade is a H5N1 virus comprising:
a. a polynucleotide encoding a second H5 protein of influenza virus, wherein said second H5 protein encodes an amino acid sequence comprising:
i. the amino acids 113D, 126H, 145(−), 156R, 160F, 167T, and 181N, wherein the modification 145(−) means that amino acid position 145 of H5 is deleted, orii. the amino acids 87P, 145L, 172T, 201E, 206I, 208K, 254T, 341G and 421K, oriii. the amino acids 145L, 172T, and 254V,
wherein the numbering of the amino acid positions of the second H5 protein of group (i), (ii), and (iii) refers to the amino acid position as exemplarily given in SEQ ID NO:8, oriv. an amino acid sequence which is at least 95%, preferably at least 96%, more preferably at least 97%, still more preferably at least 98%, yet more preferably at least 99%, or in particular preferred 100% homolog with any one of the sequences as set forth in SEQ ID NOs: 62 to 137 or 9 to 46; or b. a second H5 protein of influenza virus, wherein said second H5 protein comprises an amino acid sequence which is at least 95%, preferably at least 96%, more preferably at least 97%, still more preferably at least 98%, yet more preferably at least 99%, or in particular preferred 100% homolog with any one of the sequences as set forth in SEQ ID NOs: 62 to 137. |
