The present invention provides heterocyclic derivatives which activate the IP receptor. Activating the IP receptor signaling pathway is useful to treat many forms of PAH, pulmonary fibrosis and exert beneficial effects in fibrotic conditions of various organs in animal models and in patients. Pharmaceutical compositions comprising such derivatives are also encompassed.
申请公布号
WO2014125413(A1)
申请公布日期
2014.08.21
申请号
WO2014IB58905
申请日期
2014.02.11
申请人
NOVARTIS AG;BUTLER, REBECCA;LEBLANC, CATHERINE;MCKEOWN, STEPHEN CARL;CHARLTON, STEVEN JOHN
发明人
BUTLER, REBECCA;LEBLANC, CATHERINE;MCKEOWN, STEPHEN CARL;CHARLTON, STEVEN JOHN