| 摘要 |
The invention provides certain N-acyloxysulfonamide and N-hydroxy-N-acylsulfonamide derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the invention provides methods of using such compounds or pharmaceutical compositions for treating, preventing, or delaying the onset and/or develop of a disease or condition. In some embodiments, the disease or condition is selected from cardiovascular diseases, ischemia, reperfusion injury, cancerous disease, pulmonary hypertension and conditions responsive to nitroxyl therapy. |
| 主权项 |
1. A compound of formula (I)or a pharmaceutically acceptable salt, hydrate, or solvate thereof wherein:
L is a bond, —SO2— or —O—; Y is W, alkyl or aryl, wherein said alkyl and aryl are unsubstituted or substituted with one or more substituents independently selected from W; W is halo, —OH, —CN, —NO2, —COR1, —COOR1, —CONR1R2, —CH(C(O)R1)2, —SO2R1, or —COX, wherein X is halo and R1 and R2 are independently alkyl or aryl, or R1 and R2 are taken together to form a cycloalkyl or heterocycloalkyl, wherein said cycloalkyl and heterocycloalkyl are unsubstituted or substituted with one or more substituents; R is hydrogen, alkyl, heterocycloalkyl, aryl, benzyl, alkoxy, heterocycloalkoxy, aryloxy, benzyloxy, —NR3R4 or —N(OR3)R4, wherein said alkyl, heterocycloalkyl, aryl, benzyl, alkoxy, heterocycloalkoxy, aryloxy and benzyloxy are unsubstituted or substituted with one or more substituents; and R3 and R4 are independently alkyl, heterocycloalkyl or aryl, wherein said alkyl, heterocycloalkyl and aryl are unsubstituted or substituted with one or more substituents; provided that when L is —SO2— and R is methyl, then Y is not phenyl; and provided that when Y is W and W is —OH, then L is a bond. |
