| 发明名称 |
HIGH PH PROTEIN REFOLDING METHODS |
| 摘要 |
<p>Provided herein are methods for refolding denatured protein (e.g., from inclusion bodies) that do not require the use of a denaturing agent. Exemplary methods use a high pH for solubilizing denatured protein, followed by a decrease in pH for refolding the proteins.</p> |
| 申请公布号 |
WO2014126884(A1) |
申请公布日期 |
2014.08.21 |
| 申请号 |
WO2014US15702 |
申请日期 |
2014.02.11 |
| 申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
HOLLANDER, CRISTOPHER;BLUM, BENJAMIN C. |
| 分类号 |
C07K1/113;C07K14/00 |
主分类号 |
C07K1/113 |
| 代理机构 |
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| 主权项 |
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| 地址 |
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