发明名称 |
ANTI-CDH3 HUMANIZED ANTIBODY, DRUG CONJUGATE THEREOF, AND USE THEREOF |
摘要 |
The present invention addresses the problem of producing an anti-CDH3 humanized antibody having lower immunogenicity and provide an anti-CDH3 humanized antibody-drug conjugate using the same, said anti-CDH3 humanized antibody-drug conjugate being capable of more efficiently killing CDH3-expressing cancer cells. Provided is an anti-CDH3 humanized antibody-drug conjugate produced by linking an anti-CDH3 humanized antibody to a cytotoxic drug, wherein: the anti-CDH3 humanized antibody comprises complementarity determining region sequences originated from the heavy chain variable region of an antibody that is produced by a cell (Deposition No. NITE BP-1536) and complementarity determining region sequences originated from the light chain variable region thereof; the framework region sequences in the heavy chain variable region comprise a heavy chain human subgroup III consensus framework sequence or a human germ line sequence selected at the optimum alignment; and the framework region sequences in the light chain variable region include a light chain human ? subgroup I consensus framework sequence or a human germ line sequence selected at the optimum alignment. |
申请公布号 |
CA2901214(A1) |
申请公布日期 |
2014.08.21 |
申请号 |
CA20142901214 |
申请日期 |
2014.02.14 |
申请人 |
PERSEUS PROTEOMICS INC. |
发明人 |
ISHII, KEISUKE;MITOMO, KATSUYUKI;KOUDA, KATSUSHI;NOMURA, FUMIKO;KAYUKAWA, YOKO;MATSUURA, TADASHI |
分类号 |
C12N15/09;A61K39/395;A61P35/00;C07K16/28;C07K16/46 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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