TOLEROGENIC SYNTHETIC NANOCARRIERS FOR GENERATING CD8+REGULATORY T CELLS.

摘要

Disclosed are synthetic nanocarrier methods, and related compositions, comprising administering MHC Class I-restricted and/or MHC Class II-restricted epitopes of an antigen and immunosuppressants in order to generate tolerogenic immune responses against the antigen, such as the generation of antigen- specific CD8+ regulatory T cells.