| 摘要 |
PROBLEM TO BE SOLVED: To provide a polynucleotide sequence of a nontypeable stain of haemophilus influenzae (NTHi), to provide polypeptides encoded by the polynucleotides, and to provide uses thereof.SOLUTION: The invention also relates to NTHi genes which are upregulated during or in response to NTHi infection of an auris media and/or the nasopharynx. The invention also provides an antibody specific for a NTHi polypeptide of the invention. Methods of detecting NTHi bacteria in a human or in sample, such as serum, sputum, ear fluid, blood, urine, lymph and cerebrospinal fluid are contemplated. These methods include detecting NTHi polynucleotides with specific polynucleotide probes or detecting NTHi polypeptides with specific antibodies. The invention also contemplates diagnostic kits which utilize these methods of detecting NTHi bacteria. |
