发明名称 |
PHARMACEUTICAL COMPOSITION ON THE BASIS OF NANOMICELLES CONTAINING EPIGALLOCATECHIN GALLATE AND A METHOD OF ADMINISTRATION THEREOF TO TREAT ATOPIC DERMATITIS, CROHN'S DISEASE, ADENOMYOSIS, AND HYPERPLASTIC DISEASES OF THE PROSTATE GLAND |
摘要 |
The invention relates to pharmacy. It is an object of the present invention to produce nanomicellar structures containing EGCG and achieving a positive result consisting in increasing bioavailability in peroral administration. The object of this invention is achieved by a new pharmaceutical composition for peroral administration containing epigallocatechin-3-gallate as the active component and a target additive that is a block copolymer of oxyethylene and oxypropylene, in which the content of the hydrophobic block is less than 50% by mass and the hydrophilic block has a molecular weight of 2,250 daltons or more at a ratio of the block copolymer to the active component ranging from 1:1 to 10:1. The composition improves absorption of the active compound by the blood flow when delivered perorally. |
申请公布号 |
US2014235708(A1) |
申请公布日期 |
2014.08.21 |
申请号 |
US201414263011 |
申请日期 |
2014.04.28 |
申请人 |
KISELEV Vsevolod Ivanovich;VASILYEVA Irina Gennadievna |
发明人 |
KISELEV Vsevolod Ivanovich;VASILYEVA Irina Gennadievna |
分类号 |
A61K47/34;A61K31/353 |
主分类号 |
A61K47/34 |
代理机构 |
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代理人 |
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主权项 |
1. A pharmaceutical composition for peroral administration containing epigallocatechin-3-gallate as an active component and a target additive, having a block copolymer of oxyethylene and oxypropylene as the target additive wherein the content of the hydrophobic block is less than 50% by mass and the hydrophilic block has a molecular weight of 2,250 daltons or more, at a weight ratio of the block copolymer to the active component ranging from 1:1 to 10:1. |
地址 |
Moscow RU |