HSF1 AS A MARKER IN TUMOR PROGNOSIS AND TREATMENT

摘要

In some aspects, the invention relates to Heat Shock Protein-1 (HSF1) gene and HSF1 gene products. In some aspects, the invention provides methods of tumor diagnosis, prognosis, treatment-specific prediction, or treatment selection, the methods comprising assessing the level of HSF1 expression or HSF1 activation in a sample obtained from the tumor. In some aspects, the invention relates to the discovery that increased HSF1 expression and increased HSF1 activation correlate with poor outcome in cancer, e.g., breast cancer.

主权项

1. A method of diagnosing cancer in a subject comprising the steps of: determining the level of Heat Shock Factor-1 (HSF1) expression or the level of HSF1 activation in a sample obtained from the subject, wherein increased HSF1 expression or increased HSF1 activation in the sample is indicative that the subject has cancer.