| 摘要 |
According to the present invention there is provided a composite material comprising a covalently coupled polymer-bioglass, wherein the polymer is either functionalised with a coupling agent or includes a co-monomer coupling agent adapted to covalently couple the polymer and bioglass. The invention also relates to a method of production of a composite material comprising the steps of: preparing an inorganic sol of bioglass precursors; preparing an organic sol of polymer; combining the inorganic sol and said organic sol under such conditions to produce a covalently coupled polymer-bioglass composite material. The method further relates to forming a composite material in situ or in vivo, comprising the steps of delivering to a subject in need thereof a polymer sol and a bioglass sol to a predetermined location in the body of the subject and in situ catalysing the formation of a hybrid bioglass-polymer composite material. The method also relates to a formulation for preparing a composite material, and a kit comprising in separate containers: a bioglass sol, a copolymer sol and a catalyst. The invention further relates to the use of a hybrid composite as a bone filler, as an injectable formulation, or as a porous scaffold for biomedical purposes. A method for improving the long term stability of an implantable medical device is disclosed, and a method for regenerating or resurfacing tissue, comprising the step of: contacting said tissue with the hybrid composite of the invention. |
