COMPUESTOS NOVEDOSOS DE BENZOPIRANO, COMPOSICIONES Y USOS DE LOS MISMOS
摘要
<p>Benzopyran compounds with strong anti-estrogenic activity and essentially no estrogenic activity are provided, which are OP-1038, which is 3-(4-hydroxyphenyl)-4-methyl-2-(4-{2-[(3R)-3-methylpyrrolidin-1-yl]ethoxy}phenyl)-2H-chromen-7-ol, and OP-1074, which is (2S)-3-(4-hydroxyphenyl)-4-methyl-2-(4-{2-[(3R)-3-methylpyrrolidin-1-yl]ethoxy}phenyl)-2H-chromen-7-ol. OP-1074 is a pure anti-estrogen when tested in the agonist mode and a complete anti-estrogen when tested in the antagonist mode. These compounds are useful for the treatment or prevention of a variety of conditions that are modulated through the estrogen receptor in mammals including humans.</p>
申请公布号
CR20140259(A)
申请公布日期
2014.08.21
申请号
CR20140259
申请日期
2014.05.28
申请人
OLEMA PHARMACEUTICALS, INC
发明人
KUSHNER, PETER, J.;MYLES, DAVID, C;HARMON, CYRUS, L.;GALLAGHER, LESLIE, CAROL HODGES