METHOD FOR PREPARATION OF A CONTROLLED RELEASE SYSTEM

摘要

The present invention relates to a method for the preparation of a controlled release system and especially to a method for entrapment of compounds in polymer carriers for controlled release of active ingredients, preferably bioactive ingredients, such as drugs. This method results in a system for controlled release of active ingredients and especially for controlled drug delivery. In accordance with the present invention, the term “controlled release” encompasses all kinds of controlled release, including slow release, sustained and delayed release. Particularly, the present invention results in active ingredients, entrapped in or otherwise incorporated in or coupled to polymer carriers or polymeric devices, such as micelles, nanoparticles, microspheres and other types of polymer devices for controlled release; the active ingredients are covalently bonded to the polymer carriers or polymeric devices.

主权项

1. A controlled release system which is a three-dimensionally cross-linked intertwined polymer network comprising active ingredient molecules covalently coupled through a biodegradable linker to, and entrapped in, said three-dimensionally cross-linked polymer network, wherein said intertwined network results from crosslinking polymer chains containing polymerisable moieties and polymerisable moieties linked to said active ingredient in a free radical-initiated reaction.