发明名称 |
COMPOSITIONS AND METHODS FOR TREATING BIOFILMS |
摘要 |
<p>The present invention relates to novel methods and compositions comprising a compound, preferably perhexiline (maleate), drospirenone or toremiphene (citrate), which increases the susceptibility and sensitivity of biofi!ms to antifungal drugs such as amphotericin B and caspofungin. Accordingly, the present invention relates to use of said composition for the treatment or prevention of biofilms, particularly fungal or yeast biofilms, such as Candida biofilms, in a subject or on a surface or other medium susceptible to biofilm formation. Coating of medical devices, like implants and plastics with said compounds, in combination with conventional antifungal therapy for the treatment or prevention of biofilms is also contemplated.</p> |
申请公布号 |
WO2014124504(A1) |
申请公布日期 |
2014.08.21 |
申请号 |
WO2014BE00010 |
申请日期 |
2014.02.13 |
申请人 |
KATHOLIEKE UNIVERSITEIT LEUVEN KU LEUVEN RESEARCH& DEVELOPMENT |
发明人 |
CAMMUE, BRUNO;DE BRUCKER, KATRIJN;DELATTIN, NICOLAS;THEVISSEN, KARIN |
分类号 |
A61K31/138;A61K31/401;A61K31/4458;A61K31/585;A61K31/7048;A61P31/10 |
主分类号 |
A61K31/138 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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