发明名称 |
Nortriptyline, haloperidol or prochlorperazine edisylate for use in the treatment of tuberculosis as well as two screening methods |
摘要 |
The present invention relates to a compound capable of killing mycobacteria by activating host cellular mechanisms for use in treating tuberculosis, wherein the compound is selected from the group consisting of nortriptyline, haloperidol and prochlorperazine edisylate (PE). Furthermore, the present invention relates to a pharmaceutical composition comprising the compound of the invention, and optionally a pharmaceutically acceptable carrier. The invention further relates to a method of treating tuberculosis as well as a method of identifying a lead compound for the treatment of tuberculosis. |
申请公布号 |
EP2767275(A1) |
申请公布日期 |
2014.08.20 |
申请号 |
EP20130155069 |
申请日期 |
2013.02.13 |
申请人 |
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. |
发明人 |
SUNDARAMURTHY, VARADHARAJAN;BARSACCHI, RICO;ZERIAL, MARINO;BICKLE, MARC;KALAITZIDIS, IOANNIS;SAMUSIK, NIKOLAY |
分类号 |
A61K31/135;A61K31/4515;A61K31/5415;A61P31/06;G01N33/569 |
主分类号 |
A61K31/135 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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