Cyclic amide derivatives, and their production and use as antithrombotic agents

摘要

The present invention provides a cyclic amide derivative useful as a drug for treating thrombosis, which is represented by the formula (I):
wherein R 1 represents an optionally substituted cyclic hydrocarbon group or an optionally substituted heterocyclic group, W represents a bond or an optionally substituted divalent chain hydrocarbon group, a represents 0, 1, or 2, X 1 represents an optionally substituted lower alkylene or an optionally substituted lower alkenylene, Y 1 represents - C(O)-, -S(O)- or -S(O) 2 -, A represents a piperazine ring which may be further substituted or a piperidine ring which may be further substituted, X 2 represents a bond or an optionally substituted lower alkylene, Y 2 represents -C(O)-, -S(O)-, -S(O) 2 - or -C(=NR 7 )-, X 3 represents an optionally substituted C 1-4 alkylene or an optionally substituted C 2-4 alkenylene, Z 3 represents -N(R 4 )-, -O- or a bond, Z 1 represents -C(R 2 )(R 2' )-, -N(R 2 )-, etc., and Z 2 represents - C(R 3 )(R 3' )-, -N(R 3 )-, etc., or a salt thereof.