发明名称 |
METHOD FOR PRODUCTION OF ANTIBODY |
摘要 |
The present invention provides a method of producing a recombinant antibody efficiently and at low cost. Disclosed is a method of producing an antibody or a fragment thereof, comprising allowing a cell to produce the antibody or the fragment, wherein the cell contains a larger number of copies of an exogenous DNA encoding the light chain or a fragment thereof of the antibody than the number of copies contained in the cell of an exogenous DNA encoding the heavy chain or a fragment thereof of the antibody. The present invention also provides a recombinant vector comprising one copy of a DNA encoding the heavy chain or a fragment thereof of an antibody and two or more copies of a DNA encoding the light chain or a fragment thereof of the antibody; and a transformant. |
申请公布号 |
EP2202307(B1) |
申请公布日期 |
2014.08.20 |
申请号 |
EP20080838661 |
申请日期 |
2008.10.14 |
申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
YAMADA, YOSHIKI;KIYASU, TATSUYA;TABATA, KAZUYUKI;KUZUMAKI, AKIHIRO;YAMASHIRO, MAI |
分类号 |
C12N15/09;C12N5/10;C12P21/02 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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