Targeting opposite strand replication intermediates of single-stranded viruses by RNAI
摘要
<p>The invention relates to methods and compositions for modulating viral replication through double-stranded RNA-mediated gene silencing (RNAi), wherein the antiviral methods and compositions preferentially target opposite strand replication intermediates of single-stranded RNA viruses.</p>
申请公布号
EP2325314(B1)
申请公布日期
2014.08.20
申请号
EP20100181465
申请日期
2005.09.26
申请人
ALNYLAM PHARMACEUTICALS, INC.
发明人
MCCALLUS, DANIEL E.;GU, BACHUA;PACHUK, CATHERINE J.