| 发明名称 | Therapeutic compositions | ||
| 摘要 | This application relates to therapeutic siRNA agents and methods of making and using the agents. | ||
| 申请公布号 | US8809516(B2) | 申请公布日期 | 2014.08.19 |
| 申请号 | US201213626196 | 申请日期 | 2012.09.25 |
| 申请人 | Alnylam Pharmaceuticals, Inc. | 发明人 | Manoharan Muthiah;Rajeev Kallanthottathil G.;Bumcrot David |
| 分类号 | C07H21/02;C12N15/113 | 主分类号 | C07H21/02 |
| 代理机构 | LeClairRyan | 代理人 | Townes Jeffrey N.;LeClairRyan |
| 主权项 | 1. An iRNA agent, comprising: a sense strand sequence having 4-12 asymmetrical 2′-O-alkyl modifications, at least 4 of which occur within the 6 terminal nucleotides of the 5′ end; and an antisense sequence having at least 4 asymmetrical phosphorothioate modifications. | ||
| 地址 | Cambridge MA US | ||