| 发明名称 | Optimized Fc variants and methods for their generation | ||
| 摘要 | The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants. | ||
| 申请公布号 | US8809503(B2) | 申请公布日期 | 2014.08.19 |
| 申请号 | US201313898386 | 申请日期 | 2013.05.20 |
| 申请人 | Xencor, Inc. | 发明人 | Lazar Gregory Alan;Chirino Arthur J.;Dang Wei;Desjarlais John;Doberstein Stephen K.;Hayes Robert J.;Karki Sher Bahadur;Vafa Omid |
| 分类号 | C07K16/00;C12P21/08;C07K1/00;A61K39/395;A61K39/42;A61K39/00;C07K14/00 | 主分类号 | C07K16/00 |
| 代理机构 | Morgan, Lewis & Bockius LLP | 代理人 | Morgan, Lewis & Bockius LLP ;Silva Robin;Wong Ada O. |
| 主权项 | 1. A variant Fc region of a human parent IgG1 Fc region, wherein said variant Fc region comprises an amino acid substitution in the human parent Fc region at position 264, wherein said variant Fc region exhibits altered binding affinity to an Fcγreceptor (FcγR) as compared to a parent Fc region and wherein numbering is according to the EU index. | ||
| 地址 | Monrovia CA US | ||