Biomarkers for impaired glucose tolerance and methods using the same

摘要

Biomarkers relating to insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy are provided, as well as methods for using such biomarkers as biomarkers for insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy. In addition, methods for modulating the respective disorders or conditions of a subject are also provided. Also provided are suites of small molecule entities as biomarkers for insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy.

主权项

1. A method of classifying a subject according to glucose tolerance as having normal glucose tolerance (NGT), impaired glucose tolerance (IGT), or type-2 diabetes, the method comprising:
analyzing a biological sample from a subject to determine a level(s) of one or more biomarkers for glucose tolerance in the sample, wherein the one or more biomarkers are selected from the group consisting of 2-hydroxybutyrate, pantothenate, linoleoyl LPC, and 4-methyl-2-oxopentanoate; and comparing the level(s) of the one or more biomarkers in the sample to glucose tolerance reference levels of the one or more biomarkers in order to classify the subject as having NGT, IGT, or type-2 diabetes.