Method and apparatus for automated control of pacing post-conditioning

摘要

Pacing post-conditioning (PPC) therapy is applied to a patient to minimize ischemic injury associated with MI and/or reperfusion injury associated with a post-MI revascularization procedure. In various embodiments, a PPC therapy is delivered by executing a pacing protocol with pacing parameters determined and dynamically adjusted based on patient-specific factors to ensure efficacy and safety of the patient.

主权项

1. A cardiac pacing system, comprising:
a pacing output circuit to deliver pacing pulses; a storage device; one or more pacing post-conditioning (PPC) protocols stored in the storage device, the one or more PPC protocols each specifying a pacing sequence including alternating non-pacing and pacing periods, the non-pacing periods each including a non-pacing duration during which no pacing pulse is timed to be delivered, the pacing periods each including a pacing duration during which a plurality of pacing pulses is timed to be delivered according to a stress augmentation pacing mode adapted to augment myocardial mechanical stress to a level effecting cardioprotection against myocardial injury; a pacing control circuit coupled to the pacing output circuit and the storage device, the pacing control circuit programmed to execute a current pacing protocol and including:
a parameter input configured to receive one or more protocol generation parameters including at least one or more physiological parameters; anda protocol generator programmed to generate the current pacing protocol using the one or more PPC protocols and the one or more protocol generation parameters, the current pacing protocol specifying a plurality of pacing parameters, the one or more protocol generation parameters used to calculate one or more pacing parameters of the plurality of pacing parameters.