| 发明名称 | Fast wet-massing method for the preparation of calcium-containing compositions | ||
| 摘要 | The present invention relates to a novel process for the preparation of a granulate comprising a calcium-containing compound as an active substance. The method comprises a method for the preparation of a granulate comprising a calcium-containing compound as an active substance, the method comprising, i) feeding a granulation chamber with a composition comprising the calcium-containing compound, ii) wet-massing the composition with a granulation liquid optionally comprising a pharmaceutically acceptable binder for a time period of at the most 30 sec to obtain a wet granulate, iii) drying the thus obtained wet granulate. A granulate obtained by the present method is especially suitable in the preparation of solid dosage forms, in particular in the preparation of tablets. | ||
| 申请公布号 | US8808735(B2) | 申请公布日期 | 2014.08.19 |
| 申请号 | US200611883536 | 申请日期 | 2006.02.02 |
| 申请人 | Takeda Nycomed AS | 发明人 | Bertelsen Poul Egon;Olsen Peder Mohr;Nielsen Carsten Martini;Tolleshaug Magnus Wilhelm |
| 分类号 | A61K9/48;A61K33/10;A61K9/20 | 主分类号 | A61K9/48 |
| 代理机构 | Edwards Wildman Palmer LLP | 代理人 | Edwards Wildman Palmer LLP ;Corless Peter F. |
| 主权项 | 1. A method for the preparation of a granulate comprising calcium carbonate as an active substance, the method comprising, i) feeding a granulation chamber with a composition comprising the calcium carbonate, wherein the granulation chamber is fed with a feeding rate of from about 200 to about 1000 kg/h; ii) wet-massing the composition with a granulation liquid comprising a pharmaceutically acceptable binder for a time period of at the most 30 sec to obtain a wet granulate, wherein the granulation liquid is sprayed on the composition at a spray rate in a range of from about 15 to about 100 kg/h; and iii) drying the thus obtained wet granulate;wherein a tablet prepared from the granulate has excellent taste and mouth-feel. | ||
| 地址 | Asker NO | ||