Polymers containing poly(ester amides) and agents for use with medical articles and methods of fabricating the same

摘要

Polymers containing poly(ester amides) and agents for use with medical articles and methods of fabricating the same are disclosed. The medical article generally comprises an implantable substrate having a coating, and the coating contains a polymer comprising a polymeric product of a reaction comprising a polyol, a polycarboxylic acid, an amino acid and an agent.

主权项

1. A coating for an implantable medical device comprising a polymer of formula: wherein A is B is wherein the polymer is amino-terminated or carboxy-terminated; where R1 and R5 are optional and are independently selected from the group consisting of substituted, unsubstituted, hetero-, straight-chained, branched, cyclic, saturated and unsaturated aliphatic radicals; and substituted, unsubstituted, and hetero-aromatic radicals; R3 is selected from the group consisting of substituted, unsubstituted, hetero-, straight-chained, branched, cyclic, saturated and unsaturated aliphatic radicals; and substituted, unsubstituted, and hetero-aromatic radicals; R2, R4 and R7 are independently selected from the group consisting of hydrogen; substituted, unsubstituted, hetero-, straight-chained, branched, cyclic, saturated and unsaturated aliphatic radicals; and substituted, unsubstituted, and hetero-aromatic radicals; R6 is selected from the group consisting of substituted, unsubstituted, hetero-straight-chained and branched aliphatic radicals; L1 is an optional linkage connecting A to B and, if present, comprises a disulfide, poly(ethylene glycol), methoxypoly(ethylene glycol), poly(ethylene oxide), poly(propylene glycol), poly(tetramethylene glycol), poly(ethylene oxide-co-propylene oxide), or a copolymer thereof; X is a biobeneficial agent selected from the group consisting of poly(alkylene glycols), methoxypoly(ethylene glycol), poly(N-vinyl pyrrolidone), poly(acrylamide methyl propane sulfonic acid), poly(styrene sulfonate), sulfonated dextran, polyphosphazenes, poly(orthoesters), poly(tyrosine carbonate), hyaluronic acid, heparin, a graft copolymer of poly(L-lysine) and poly(ethylene glycol), and salts, copolymers and combinations thereof; a free radical scavenger, a nitric oxide donor, rapamycin, tacrolimus, paclitaxel, docetaxel, estradiol, clobetasol, idoxifene, tazarotene, and salts and combinations thereof; antiproliferatives, antineoplastics, antimitotics, anti-inflammatories, antiplatelets, anticoagulants, antifibrins, antithrombins, antibiotics, antiallergics, antioxidants, and salts and combinations thereof; 40-O-(2-hydroxy)ethyl-rapamycin (everolimus), 40-O-(3-hydroxypropyl)-rapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethyl-rapamycin, and salts and combinations thereof; L2 is a linkage connecting X to the polymer; and n and m are independently integers not equal to 0.