Malaria vaccine

摘要

The present invention provides a vaccine for preventing and/or treating Plasmodium falciparum infections, which comprises a polypeptide set forth in SEQ ID NO: 1 or represented by formula (1), and an adjuvant.
X1-A-B-X2-Y-X3-(Y)n-X4-(Y)n-X5  (1)
(In the formula, X1 represents the 1st to 7th amino acid residues in a polypeptide set forth in SEQ ID NO: 1; X2 represents the 73th to 177th amino acid residues; X3 represents the 178th to 258th amino acid residues; X4 represents the 259th to 289th amino acid residues; X5 represents the 290th to 334th amino acid residues; A represents an 8-mer repeat sequence contained in a 47-kd region of SERA polypeptide of Plasmodium falciparum; B represents a sequence of a serine-rich region contained in a 47-kd region of SERA polypeptide of Plasmodium falciparum; Y represents any one selected from A-A, A-B, and B; and n is an integer of 0 or 1.)

主权项

1. A polypeptide as set forth in formula (1):
X1-A-B-X2-Y-X3-(Y)n-X4-(Y)n-X5  (1) wherein X1 represents the 1st to 7th amino acid residues in a polypeptide set forth in SEQ ID NO: 1; X2 represents the 73th to 177th amino acid residues of the polypeptide set forth in SEQ ID NO: 1; X3 represents the 178th to 258th amino acid residues of the polypeptide set forth in SEQ ID NO: 1; X4 represents the 259th to 289th amino acid residues of the polypeptide set forth in SEQ ID NO: 1; X5 represents the 290th to 334th amino acid residues of the polypeptide set forth in SEQ ID NO: 1; A represents an 8-mer repeat sequence contained in a 47-kd region of a SERA polypeptide of Plasmodium falciparum; B represents the amino acid sequence set forth in SEQ ID NO: 9; Y represents any one selected from A-A, A-B, and B; and n represents an integer of 0 or 1.