发明名称 |
HUMANIZED ANTI-TAG-72 CC49 FOR DIAGNOSIS AND THERAPY OF HUMAN TUMORS |
摘要 |
The present disclosure provides humanized CC49 monoclonal antibodies that bind TAG-72 with high binding affinity and that are minimally immunogenic. In one embodiment, a humanized CC49 antibody includes a non-conservative amino acid substitution in a light chain complementarity determining region 3 of the CC49 antibody. In a further embodiment, the humanized CC49 antibody includes a non-conservative substitution of a first residue in a light chain complementarity determining region 3 and a substitution of a second residue in a complementarity determining region of the humanized CC49 antibody. In several of the embodiments, methods are disclosed for the use of a humanized CC49 antibody in the detection or treatment of a tumor in a subject. Also disclosed is a kit including the humanized CC49 antibody described herein. |
申请公布号 |
CA2490659(C) |
申请公布日期 |
2014.08.19 |
申请号 |
CA20032490659 |
申请日期 |
2003.06.26 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
KASHMIRI, SYED V. S.;SCHLOM, JEFFREY;PADLAN, EDUARDO A. |
分类号 |
C07K16/46;A61K39/395;A61K49/00;A61K51/00;A61K51/10;A61P35/00;C07K16/30;C12N15/13;G01N33/574 |
主分类号 |
C07K16/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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