Method of preparing an immunologically-active adjuvant-bound dried vaccine composition

摘要

The disclosure provides a method of preparing an immunologically-active adjuvant-bound freeze dried vaccine composition. A specific embodiment provides a stable vaccine composition comprising an aluminum-salt adjuvant, a recombinant Clostridium botulinum neurotoxin protein and a glass-forming agent. These vaccine compositions are useful in the treatment of humans and other animals at risk of infection from Clostridium botulinum neurotoxin.

主权项

1. A freeze dried composition comprising:
a. an aluminum-salt adjuvant, b. a glass-forming agent, c. a buffer salt, and d. a recombinant antigen, wherein the antigen is selected from the group consisting of toxins and viruses.