Chroman-derived anti-androgens for treatment of androgen mediated disorders

摘要

Methods for the prevention and/or alleviation of androgen-mediated disorders treatable by administering a chroman-derived anti-androgen compound are provided by the present invention. The invention further provides pharmaceutical and nutraceutical compositions containing chroman-derived anti-androgen compounds useful in the prevention and/or alleviation of androgen-mediated disorders, particularly prostate cancer.

主权项

1. A method for treating an androgen-mediated disorder selected from the group consisting of hirsutism, acne, seborrhea, androgenic alopecia, hyperpilosity, benign prostatic hypertrophy, adenomas or neoplasias of the prostate, polycystic ovary syndrome, and androgen supplement induced disorders, comprising administering to a patient having the androgen-mediated disorder an effective amount of:
(a) a compound having the formula: or (b) a pharmaceutically acceptable salt of said compound; wherein the androgen-mediated disorder is effectively treated by the compound binding to and acting as an antagonist of the androgen receptor.