Imidazole, pyrazole, and triazole derivatives useful as antibacterial agents

摘要

The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections.

主权项

1. A compound of Formula Ior a pharmaceutically acceptable salt thereof;
wherein
R1 is (C1-C3)alkyl;R2 is hydrogen or (C1-C3)alkyl;R3 is hydrogen or (C1-C3)alkyl;X is N or CR4;Y is N or CR4;R4 is hydrogen or (C1-C3)alkyl;L is a bond, (C2-C6)alkenylene, (C1-C6)alkylene, (C2-C6)alkynylene, —(CH2)nO(CH2)p—, —(CH2)nS(CH2)p—, —(CH2)nNR5(CH2)p—, —(CH2)nSO2NR5(CH2)p—, —(CH2)nNR5SO2(CH2)p—, —(CH2)nCONR5(CH2)p—, or —(CH2)nNR5CO(CH2)p—;R5 and R6 are independently hydrogen, (C1-C6)alkyl, (C1-C6)alkylcarbonyl, (C3-C8)cycloalkyl, (C3-C8)cycloalkyl(C1-C6)alkyl, or formyl;n is 0, 1, 2, 3, or 4;p is 0, 1, 2, 3, or 4;R7 is (C2-C6)alkenyl, (C1-C6)alkoxy, (C1-C6)alkoxy(C1-C6)alkyl, (C1-C6)alkoxycarbonyl, (C1-C6)alkyl, (C1-C6)alkylcarbonyl, (C1-C6)alkyl-NR5—(C1-C6)alkyl, (C1-C6)alkylthio, (C1-C6)alkylthio(C1-C6)alkyl, (C1-C6)alkylthiocarbonyl, (C2-C6)alkynyl, (C6-C12)aryl, (C6-C12)aryloxy, (C6-C12)arylthio, (C6-C12)aryl-NR5—, cyano, cyano(C1-C6)alkyl, (C5-C8)cycloalkenyl, (C3-C8)cycloalkyl, (C3-C8)cycloalkyloxy, (C3-C8)cycloalkylthio, (C3-C8)cycloalkyl-NR5—, (C5-C12)heteroaryl, (C5-C12)heteroaryloxy, (C5-C12)heteroarylthio, (C5-C12)heteroaryl-NR5—, (C3-C13)heterocycle, (C3-C13)heterocycleoxy, (C3-C13)heterocyclethio, (C3-C13)heterocycle-NR5—, hydroxy(C1-C10)alkyl, mercapto(C1-C6)alkyl, (NR5R6)alkyl, or (NR5R6)carbonyl; andR8 is absent, (C6-C12)aryl, (C6-C12)aryl(C1-C6)alkyl, (C3-C8)cycloalkyl, (C3-C8)cycloalkyl(C1-C6)alkyl, (C5-C12)heteroaryl, (C5-C12)heteroaryl(C1-C6)alkyl, (C3-C13)heterocycle, or (C3-C13)heterocycle(C1-C6)alkyl.