| 发明名称 |
Sulfonamides as TRPM8 modulators |
| 摘要 |
Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows:;
wherein A, B, G, Y, R1, R2, R3, and R4 are defined herein. |
| 申请公布号 |
US8809327(B2) |
申请公布日期 |
2014.08.19 |
| 申请号 |
US201213407251 |
申请日期 |
2012.02.28 |
| 申请人 |
Janssen Pharmaceutica, NV |
发明人 |
Branum Shawn T.;Colburn Raymond W.;Dax Scott L.;Flores Christopher M.;Jetter Michele C.;Liu Yi;Ludovici Donald;Macielag Mark J.;Matthews Jay M.;McNally James J.;Reaney Laura M.;Russell Ronald K.;Qin Ning;Teleha Christopher;Wells Kenneth M.;Youells Scott C.;Youngman Mark A. |
| 分类号 |
A61K31/381;A61K31/541;A61K31/4709;A61K31/5377;A61P29/02 |
主分类号 |
A61K31/381 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for treating inflammatory hyperalgesia in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a compound selected from the group consisting of: N-(3-Methyl-benzo[b]thiophen-2-yl)-N-(4-fluoro-3-trifluoromethyl-benzyl)-4-carboxy-benzenesulfonamide and N-(3-Methyl-benzo[b]thiophen-2-yl)-N-(4-trifluoromethoxy-benzyl)-4-carboxy-benzenesulfonamide. |
| 地址 |
BE |
