Compositions for pulmonary delivery of long-acting β₂adrenergic receptor agonists and associated methods and systems

摘要

Compositions, methods and systems are provided for pulmonary delivery of long-acting muscarinic antagonists and long-acting β2 adrenergic receptor agonists via a metered dose inhaler. In particular embodiments, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium.

主权项

1. A pharmaceutical composition deliverable from a metered dose inhaler, comprising:
a suspension medium substantially free of cosolvents and solubilizing agents and comprising a pharmaceutically acceptable propellant; a plurality of respirable active agent particles (AAP) comprising a pharmaceutically acceptable salt, ester, isomer, or solvate of formoterol; and a plurality of respirable suspending particles (RSP) formed separately from the plurality of AAP, wherein the RSP comprise a dry particulate phospholipid material that is substantially insoluble in the suspension medium, and wherein the RSP are present in the suspension medium at a concentration of up to about 30 mg/mL and at a weight ratio of total mass of RSP to total mass of AAP that ranges from above 1:1 up to 200:1.