发明名称 Salts of benzimidazole compound and use thereof
摘要 A sodium salt, magnesium salt, lithium salt, potassium salt, calcium salt or barium salt of (R)-2 -[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2 -pyridinyl]methyl]sulfinyl]-1H-benzimidazole, and a pharmaceutical composition comprising the salt. The novel salt is useful as an excellent antiulcer agent.
申请公布号 US8809542(B2) 申请公布日期 2014.08.19
申请号 US201313904609 申请日期 2013.05.29
申请人 Takeda Pharmaceutical Company Limited 发明人 Kamiyama Keiji;Hashimoto Hideo
分类号 C07D401/12 主分类号 C07D401/12
代理机构 Hamre, Schumann, Mueller & Larson. P.C. 代理人 Hamre, Schumann, Mueller & Larson. P.C.
主权项 1. A crystal of sodium salt of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole Monohydrate, wherein the X-ray diffraction spectrum have the following diffraction peaks: (iii) 8.89, 8.47, 5.64, 5.24, 4.84, 4.23, 4.20, 4.09, 3.60, and 3.36 Angstrom.
地址 Osaka JP