发明名称 |
Use of dynamin ring stabilizers |
摘要 |
There is provided a method for promoting dynamin ring formation and/or maintenance of dynamin rings in a cell, comprising treating the cell with an effective amount of a dynamin ring stabilizer, or a prodrug or pharmaceutically acceptable salt of the dynamin ring stabilizer. The maintenance or accumulation of dynamin ring formation has particular application in the prophylaxis or treatment of a kidney disease or condition characterized by proteinuria. A dynamin ring stabilizer can be any agent that interacts with dynamin to promote dynamin ring assembly and/or inhibit dynamin ring disassembly. There are also provided methods for prophylaxis or treatment of podocyte dysfunction and/or maintaining or inducing actin cytoskeleton formation in a cell utilizing dynamin ring stabilizers, and for screening a test agent for use as a dynamin ring stabilizer. |
申请公布号 |
US8809386(B2) |
申请公布日期 |
2014.08.19 |
申请号 |
US201013321415 |
申请日期 |
2010.05.21 |
申请人 |
Children's Medical Research Institute;The General Hospital Corporation |
发明人 |
Robinson Phillip J.;Sever Sanja |
分类号 |
A61K31/35 |
主分类号 |
A61K31/35 |
代理机构 |
Rothwell, Figg, Ernst & Manbeck P.C. |
代理人 |
Rothwell, Figg, Ernst & Manbeck P.C. |
主权项 |
1. A method for prophylaxis or treatment of a kidney disease or condition characterized by proteinuria, comprising administering to an individual in need thereof an effective amount of at least one dynamin ring stabilizer for maintaining and/or inducing actin cytoskeleton formation, or prodrug or pharmaceutically acceptable salt of the dynamin ring stabilizer. |
地址 |
Westmead, NSW AU |