Susceptibility variants for peripheral arterial disease and abdominal aortic aneurysm

摘要

The present invention discloses certain genetic variants as susceptibility variants for peripheral arterial disease (PAD) and abdominal aortic aneurysm (AAA). The invention relates to risk management using such variants. The invention further relates to kits for use in risk assessment of PAD and AAA.

主权项

1. A method for determining a susceptibility to peripheral arterial disease or abdominal aortic aneurysm in a human individual, the method comprising:
analyzing polymorphic marker rs1051730 in a nucleic acid sample from the human individual, detecting the presence of allele T of polymorphic marker rs1051730 in the sample, determining an increased genetic susceptibility to peripheral arterial disease or abdominal aortic aneurysm for the individual attributable to the presence of allele T of polymorphic marker rs1051730 in the sample, and performing vascular imaging, segmental pressure measurement, or pulse volume recording on the individual identified as having the increased genetic susceptibility, to monitor the development, progress, and/or appearance of symptoms of peripheral arterial disease or performing angiography or ultrasound imaging on the individual identified as having the increased genetic susceptibility to abdominal aortic aneurism, to monitor the development, progress, and/or appearance of symptoms of abdominal aortic aneurism.