发明名称 |
Imaging volumes with arbitrary geometries in contact and non-contact tomography |
摘要 |
A method for tomographic imaging of diffuse medium includes directing waves into a diffusive medium, solving a surface-bounded inversion problem by forward field calculations through decomposition of contributions from the multiple reflections from an arbitrary surface within the diffusive medium or outside the diffusive medium into a sum of different orders of reflection up to an arbitrary order, and using contact or non-contact measurements of waves outside said diffusive medium to generate a tomographic image. |
申请公布号 |
US8812088(B2) |
申请公布日期 |
2014.08.19 |
申请号 |
US201213460005 |
申请日期 |
2012.04.30 |
申请人 |
VisEn Medical, Inc. |
发明人 |
Ripoll Lorenzo Jorge;Ntziachristos Vasilis;Madden Karen |
分类号 |
A61B6/00 |
主分类号 |
A61B6/00 |
代理机构 |
Choate Hall & Stewart LLP |
代理人 |
Choate Hall & Stewart LLP |
主权项 |
1. A method for real time Diffusive Optical Tomographic (DOT) imaging of a biological tissue of a subject comprising:
(a) administering a fluorescent imaging probe to the subject for accumulation in a three-dimensional target region comprising the biological tissue, wherein the biological tissue of the subject has a volume V bounded by boundary S, and wherein the volume V is of arbitrary geometry; (b) directing excitation light waves into the biological tissue to cause the fluorescent imaging probe in the three-dimensional target region to emit fluorescent light; (c) using a detector to detect an intensity of the fluorescent light and the excitation light waves emitted from multiple points from the biological tissue by using non-contact measurements of the excitation light waves and the fluorescent light outside the biological tissue, where there is air between the detector and the biological tissue; and (d) processing the detected intensity of fluorescent light and the detected intensity of the excitation light waves to generate a tomographic image indicating the quantity of fluorescent imaging probe in the three-dimensional target region within the subject; wherein the tomographic image is generated by modeling propagation of diffuse photon waves inside the volume V taking into account the boundary surface S and a modeling of the intensities at the detector located outside the biological tissue of the subject. |
地址 |
Waltham MA US |