Method of inhibiting Alu RNA and therapeutic uses thereof

摘要

The presently-disclosed subject matter includes methods of identifying an Alu RNA inhibitor, and methods and compositions for inhibiting Alu RNA. Methods and compositions can be used for the treatment of geographic atrophy and other conditions of interest.

主权项

1. A method of protecting a retinal pigmented epithelium (RPE) cell, comprising: inhibiting Alu RNA associated with the RPE cell, wherein the inhibiting Alu RNA comprises administering an siRNA targeting Alu RNA.