| 发明名称 | Method for purification of complement factor H | ||
| 摘要 | A method for purification of complement Factor H from a complement Factor H containing source such as blood or blood plasma, in particular a caprylate precipitate of a Factor H containing source, which is e.g. obtained by addition of caprylate ions to fractions of blood or plasma, comprising the steps of: a) providing a Factor H containing source, in particular reconstitution of caprylate precipitate to provide a complement Factor H containing solution;b) performing a cation exchange chromatography in particular as first chromatographic step;c) performing an anion exchange chromatography;d) performing a hydroxyl apatite chromatography;e) followed by ultra/diafiltration to obtain a complement Factor H concentrate. | ||
| 申请公布号 | US8809510(B2) | 申请公布日期 | 2014.08.19 |
| 申请号 | US201113879283 | 申请日期 | 2011.10.13 |
| 申请人 | Octapharma AG | 发明人 | Brandstaetter Hubert;Schulz Petra;Roemisch Juergen |
| 分类号 | C07K1/18;A61K38/00;G01N30/02;C07K1/22;C07K1/36;A61K39/00;C07K14/705;A61K35/16;C07K14/47 | 主分类号 | C07K1/18 |
| 代理机构 | Venable LLP | 代理人 | Venable LLP ;Axelrod Nancy J.;Gollin Michael A. |
| 主权项 | 1. A method for purification of complement Factor H from a complement Factor H containing source, which is a caprylate precipitate obtained by the addition of caprylate ions to fractions of blood or blood plasma, comprising the steps of: a. reconstituting the caprylate precipitate to provide a complement Factor H containing solution; b. performing a cation exchange chromatography; c. performing an anion exchange chromatography; d. performing a hydroxyl apatite chromatography; e. followed by ultra/diafiltration to obtain a complement Factor H concentrate. | ||
| 地址 | Lachen CH | ||