摘要 |
Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I), or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle. |
申请人 |
VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
CHARIFSON, PAUL S.;CLARK, MICHEL P.;BANDARAGE, UPUL K.;BETHIEL, RANDY S.;BOYD, MICHAEL J.;DENG, HONGBO;DUFFY, JOHN P.;FARMER, LUC J.;GAO, HUAI;GU, WENXIN;KENNEDY, JOSEPH M.;LEDFORD, BRIAN;LEDEBOER, MARK W;MALTAIS, FRANCOIS;PEROLA, EMANUELE;WANG, TIANSHENG;DAVIS, IOANA |