发明名称 Compuestos derivados de heterociclos nitrogenados, inhibidores de replicacion de los virus de influenza; metodo de preparacion; composicionn farmaceutica; metodo para inhibir la replicacion del virus de la influenza en una muestra biológica o un paciente.
摘要 Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I), or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.
申请公布号 CL2014000245(A1) 申请公布日期 2014.08.18
申请号 CL20140000245 申请日期 2014.01.31
申请人 VERTEX PHARMACEUTICALS INCORPORATED 发明人 CHARIFSON, PAUL S.;CLARK, MICHEL P.;BANDARAGE, UPUL K.;BETHIEL, RANDY S.;BOYD, MICHAEL J.;DENG, HONGBO;DUFFY, JOHN P.;FARMER, LUC J.;GAO, HUAI;GU, WENXIN;KENNEDY, JOSEPH M.;LEDFORD, BRIAN;LEDEBOER, MARK W;MALTAIS, FRANCOIS;PEROLA, EMANUELE;WANG, TIANSHENG;DAVIS, IOANA
分类号 C07D471/04;A61K31/506;A61P31/16 主分类号 C07D471/04
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