SUBSTITUTED BISPHENYL BUTANOIC PHOSPHONIC ACID DERIVATIVES AS NEP INHIBITORS

摘要

The present invention provides a compound of formula I;;;or a pharmaceutically acceptable salt thereof, wherein R1, R2 and R3 are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides pharmaceutical composition of the compounds of the invention and a combination of pharmacologically active agents and a compound of the invention.

主权项

1. A compound of the formula (I): wherein: R1 is H; —C1-7alkyl or C6-10aryl; wherein alkyl is optionally substituted with one or more substituents independently selected from the group consisting of —O—C(O)—O—C3-7cycloalkyl, —O—C(O)—C3-7cycloalkyl, —O—C(O)—C6-10aryl, —O—C(O)—O—C6-10aryl, —O—C(O)—O—C1-7alkyl, —O—C(O)—C1-7alkyl, heteroaryl, heterocyclyl, —C(O)-heterocyclyl, —C(O)NH2, —C(O)NH—C1-7alkyl, and —C(O)N(C1-7alkyl)2; R2 is Cl, CH3 or F; R3 is H, F, Cl, CH3 or OCH3, or a pharmaceutically acceptable salt thereof.