WATER SOLUBLE SALTS OF ALDOSE REDUCTASE INHIBITORS FOR TREATMENT OF DIABETIC COMPLICATIONS

摘要

The present invention relates to pharmaceutically acceptable water soluble salts of aldose reductase inhibitors, 2-(8-oxo-7-((5-trifluromethyl)-1H-benzo[d]imidazol-2-yl)methyl)7,8-dihydropyrazin[2,3-d]pyridazin-5-yl)acetic acid and [4-oxo-(5-trifluoromethyl-benzothaiazol-2-ylmethyl)-3,4-dihydro-phthalazin-1-yl]-acetic acid (also known as zopolrestat), pharmaceutical compositions thereof and methods of treating diabetic complications in mammals comprising administering to mammals these salt and compositions.

主权项

1. A compound of Formula II,Formula IIX+Formula IIaFormula IIbFormula IIcFormula IIdFormula IIeFormula IIfFormula IIgwherein X+ is protonated arginine (Formula IIa), lysine (Formula IIb), aspartic acid (Formula IIc), glutamic acid (Formula IId), glucosamine (Formula IIe), glucamine (Formula IIf), and metformin (Formula IIg).