| 发明名称 |
NANOPARTICLE DELIVERY COMPOSITIONS |
| 摘要 |
Nanoparticle delivery systems for use in targeting biologically active agents to the central nervous system comprise a composition comprising (a) a nanoparticle comprising: (i) a core comprising a metal and/or a semiconductor; and (ii) a corona comprising a plurality of ligands covalently linked to the core, wherein said ligands comprise a carbohydrate, insulin and/or a glutathione; and (b) the at least one agent to be delivered to the CNS. Methods of treatment and diagnosing CNS disorders utilising the nanoparticle delivery systems and related screening methods are also disclosed. |
| 申请公布号 |
US2014227186(A1) |
申请公布日期 |
2014.08.14 |
| 申请号 |
US201414175422 |
申请日期 |
2014.02.07 |
| 申请人 |
Midatech Limited |
发明人 |
Rademacher Thomas;Male David K. |
| 分类号 |
A61K9/51;A61K38/17;A61K39/395;A61K49/18 |
主分类号 |
A61K9/51 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for delivering at least one agent to the central nervous system (CNS) of a mammalian subject, said method comprising administering a composition to the subject, said composition comprising:
(a) a nanoparticle comprising:
(i) a core comprising a metal and/or a semiconductor;(ii) a corona comprising a plurality of ligands covalently linked to the core, wherein said ligands comprise a carbohydrate, insulin and/or a glutathione; and (b) the at least one agent to be delivered to the CNS. |
| 地址 |
Abingdon GB |
