| 摘要 |
<p>PROBLEM TO BE SOLVED: To provide a method for producing a 1-substituted-3-fluoroalkylpyrazole-4-carboxylic acid ester which can produce one targeting position isomer of two position isomers with high selectivity and high yield, has high versatility and can be easily applied to an industrial process.SOLUTION: There is provided a method for producing a 1-substituted-3-fluoroalkylpyrazole-4-carboxylic acid ester which comprises a reaction step of adding a second reaction liquid containing an acyl acetic acid ester derivative and a second organic solvent to a first reaction liquid containing an alkyl hydrazine and a first organic acid and then stirring in the presence of an inorganic base, wherein the amount of the inorganic base is 0.008 mol% or more and less than 50 mol% based on the acyl acetic acid ester derivative, the total mass of the first organic solvent and the second organic solvent is 1 to 60 times the mass of the acyl acetic acid ester derivative and the amount of the first organic solvent accounts for 40 to 95 mass% of the total of the first organic solvent and the second organic solvent.</p> |
