| 摘要 |
The present invention relates to novel synthetic substituted heterocyclic compounds and pharmaceutical compositions containing the same that are capable of inhibiting or antagonizing a family of receptor tyrosine kinases, Tropomysosin Related Kinases (Trk), in particular the nerve growth factor (NGF) receptor, TrkA. The invention further concerns the use of such compounds in the treatment and/or prevention of pain, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, or a disease, disorder or injury relating to dysmyelination or demyelination or the disease or disorder associated with abnormal activities of NGF receptor TrkA. |
| 主权项 |
1. A method of treating a disease, disorder, symptom, or condition associated with irregular TrkA activity in a patient suffering therefrom, comprising:
a) administering to the patient a pharmaceutical composition, comprising:
a therapeutically effective amount of a compound having the following structure, or a salt, solvate, ester, or prodrug thereof; and at least one pharmaceutically acceptable carrier, wherein said disease, disorder, symptom, or condition associated with irregular TrkA activity in a patient is pain, cancer, psoriasis, inflammation, viral infection, or cystitis. |
