| 摘要 |
The invention relates to a pharmaceutical composition for oral administration comprising or consisting of (i) 10 to 30% weight, of at least one pharmaceutically active substance selected from the group consisting of water-soluble, oxidatively-degradable statins, preferably atorvastatin, cerivastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, simvastatin or a combination thereof, (ii) 0.01 to 3% weight, of a first anti-oxidatively active substance (A1), (iii) 0.01 to 3% weight, of a second anti-oxidatively active substance (A2) that differs from the first anti-oxidatively active substance (A1), and (iv) 60 to 85% weight of at least one additive, selected from the group consisting of filler, binder, flow-regulating agent, disintegrant and anti-blocking agent or a combination thereof, and the use of the pharmaceutical composition in medicine. |
| 主权项 |
1. Pharmaceutical composition for oral administration comprising:
(i) 10 to 30% by weight of at least one pharmaceutically active substance selected from the group consisting of water-soluble, oxidatively degradable statins, (ii) 0.01 to 3% by weight of a first anti-oxidatively active substance (A1), (iii) 0.01 to 3% by weight of a second anti-oxidatively active substance (A2), different from the first anti-oxidatively active substance (A1), and (iv) 60 to 85% by weight of at least one additive selected from the group consisting of filler, binder, flow regulating agents, disintegrant, and anti-blocking agent and combinations thereof. |
